Users Accessing Exchange from Other domains

Hi

I want to build a new AD domain and Exchange 2013 in this new domain in Site A. I will be setting up Outlook Anywhere and OWA.

I have users on other AD domains in different locations. These locations just have Internet with not network connectivity to Site A. I want users in these different locations to access the Exchange in Site A via Outlook Anywhere and OWA for mail services.

Can this work???

Since the users are on other AD domains, what are the implications for AutoDiscover???

jk