Exchange 2103 with SP1: some owa users not work

I have exchange 2013 ,

After I install new exchange 2013 with sp1 one for mail boxes and the second Client Access, i move all mail boxes to it, then i uninstall  the old server (exchange 213 with cu3).

All may exchange server’s virtual machines on hyper-v

I install certificate and configure virtual directories

I notice some users can’t open there mail boxes from OWA they get a blank page (the same users can open outlook anywhere) at the same times many users can access owa.

After many restarts they can access OWA.

After some days some other users can’t access owa.

I remove ECP and OWA virtual directories, Then Recreate and configure it.

But the same problem

I install a new client access server, configure it

But the same problem